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Current perspectives in diagnostic melanocytic tumour pathology

  • Rajiv M. Patel
    Correspondence
    Address for correspondence: Dr Rajiv M. Patel, Departments of Pathology and Dermatology, Michigan Medicine, University of Michigan, 2800 Plymouth Rd, Bldg. 35, Ann Arbor, MI 48109-2800, USA.
    Affiliations
    Departments of Pathology and Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA
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  • Andrew J. Colebatch
    Affiliations
    Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia

    Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and NSW Health Pathology, Sydney, NSW, Australia

    Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
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Published:January 16, 2023DOI:https://doi.org/10.1016/j.pathol.2023.01.001
      Scientific advances in the field of melanocytic tumour pathology have increased at a breath-taking pace over the past 50 years. Work throughout the 19th century, primarily based on morphology, established melanoma as a distinct cellular disease. The late 1960s and 1970s saw the pioneering work of Clark and Breslow delineating the prognostic value of tumour thickness in patient outcome. The 1980s saw the development of melanocytic immunohistochemistry, while the early 1990s ushered in Morton's technique of sentinel lymph node biopsy. The late 1990s and early 2000s saw the description of specific molecular abnormalities in naevi and melanoma. More recently, the development of BRAF, CTLA-4 and PD-1 inhibitors have led to completely novel treatment options for melanoma.
      • Rebecca V.W.
      • Sondak V.K.
      • Smalley K.S.M.
      A brief history of melanoma: from mummies to mutations.
      A representative sample of the most important recent work in diagnostic melanocytic tumour pathology has been distilled into this special issue. This special edition contains concise reviews and original research presented by leading world experts in melanocytic tumour pathology at the recent International Academy of Pathology (IAP) World Congress melanocytic tumour pathology course held in Sydney, Australia (11–15 October 2022). It is our privilege to compile this outstanding work into a useful compendium of up-to-date information aimed at the practising surgical pathologist, clinicians involved in the care of patients with melanocytic lesions and medical trainees.
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